A Pass Box, or Pass-Through Box, is a chamber with doors on either side, allowing the transfer of materials between controlled environments without exposing them to the external environment used in processes in pharmaceutical manufacturing and laboratory setting and minimizes the risk of contamination during material transfer. The decision to use pass boxes is influenced by factors such as the nature of the substances being handled (e.g., API), the requirement for aseptic conditions in production steps, and the need to prevent cross-contamination between different areas of the facility.